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Somarajan J. Nair

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Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

2016 ACS Medicinal Chemistry Letters
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Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926

2016 Organic Process Research & Development
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Abstract B029: The potent and selective phosphoinositide-3-kinase-gamma inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment

2016 Cancer immunology research
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Abstract A192: The potent and selective phosphoinositide-3-kinase-γ inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment

2015 Molecular Cancer Therapeutics
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A Design of Experiments Approach to a Robust Final Deprotection and Reactive Crystallization of IPI-926, A Novel Hedgehog Pathway Inhibitor

2015 Organic Process Research & Development
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The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway

2013 Xenobiotica
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Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors

2012 Journal of Medicinal Chemistry
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Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.

2008 Journal of Medicinal Chemistry
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