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E De Clercq

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Development of novel therapeutic concepts and rational anti-HIV drug design

2006
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Phenotypic resistance to tenofovir of a multinucleoside resistant HIV-1 strain containing Q151M in association with other specific mutations

2003
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The multi-nucleoside resistance phenotype characterised by the Q151M mutation in the HIV-1 reverse transcriptase is enhanced under the selective pressure of acyclic nucleotide analogs but reduced by foscarnet

2000
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In vitro selection of high level resistance towards foscarnet and acyclic nucleoside phosphonates using a patient isolate displaying the multinucleoside resistant pattern

1999
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