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Edward P. Garvey

University of California, San Francisco

15

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1071

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Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).

2013 Journal of Medicinal Chemistry
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Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant.

2009 Biochemistry
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Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.

2009 Journal of Medicinal Chemistry
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S/GSK1349572 is a Potent Next Generation HIV Integrase Inhibitor

2009
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Nucleotide and nucleoside analogues as inhibitors of cytosolic 5'-nucleotidase I from heart.

1998 Biochemistry
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Substituted N-Phenylisothioureas: Potent Inhibitors of Human Nitric Oxide Synthase with Neuronal Isoform Selectivity

1997 Journal of Medicinal Chemistry
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Purification and inhibitor screening of human nitric oxide synthase isozymes.

1996 Methods in Enzymology
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Derives substitues de l'uree et de l'isothiouree utilises comme inhibiteurs de l'oxyde nitrique synthase

1994
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Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine.

1993 Biochemistry
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Selection and properties of Leishmania tropica resistant to 10-propargyl-5,8-dideazafolate, an inhibitor of thymidylate synthetase

1985 Molecular and Biochemical Parasitology
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Citations (37)