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Joseph Therrien

Chiron Corporation

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Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif

2020 ACS Medicinal Chemistry Letters
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Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor

2018 Journal of Medicinal Chemistry
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Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856

2017 Journal of Medicinal Chemistry
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Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability

2016 Journal of Medicinal Chemistry
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Fosfomycin enhances the active transport of tobramycin in Pseudomonas aeruginosa

2012 Antimicrobial Agents and Chemotherapy
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In Vitro Metabolism Of GS-424020, A Novel Mutual Prodrug Of Salmeterol And Desisobutryl-ciclesonide, BY AIR-liquid Interface HUMAN BRONCHIAL EPITHELIAL CELLS

2010 ATS | American Thoracic Society International Conference
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