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Niek G. J. Leus

University of Groningen

12

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284

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HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

2017 Scientific Reports
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A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices

2017 Pulmonary Pharmacology & Therapeutics
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The relevance of K-i calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor

2017 European Journal of Medicinal Chemistry
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HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

2016 Biochemical Pharmacology
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The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

2016 Biochemical Pharmacology
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Activity‐Based Probes for 15‐Lipoxygenase‐1

2016 Angewandte Chemie
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Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation.

2016 Current Opinion in Chemical Biology
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Citations (64)