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Nicholas C. Nicolaides

Johns Hopkins University

86

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Block‑Removed Immunoglobulin Technology to enhance rituximab effector function by counteracting CA125‑mediated immunosuppression

2021 Oncology Letters
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Abstract 2370: Synergistic effect of carboplatin on farletuzumab (FAR) tumor cell killing via downregulation of the humoral immunosuppressive CA125 protein and enhanced antibody dependent cellular cytotoxicity (ADCC)

2019 Immunology
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CA125 suppresses amatuximab immune-effector function and elevated serum levels are associated with reduced clinical response in first line mesothelioma patients

2018 Cancer Biology & Therapy
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Tumor-shed antigen CA125 blocks complement-mediated killing via suppression of C1q-antibody binding: Immunomodulation and immune therapies

2018 European Journal of Immunology
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Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc-γ receptor engagement

2017 Oncotarget
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Abstract 644: CA125/MUC16 suppresses antibody-dependent cellular cytotoxicity of IgG1-based therapies via perturbation of antibody Fc-Receptor engagement on immune effector cells

2017 Cancer Research
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Contents Vol. 152, 2017

2017 Cytogenetic and Genome Research
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Abstract 1743: Comprehensive genomic characterization of a large cohort of platinum-sensitive, high-grade serous ovarian cancer (HGSOC) FFPE specimens

2017 Cancer Research
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Ingemar Gustavsson (1938-2016)

2017 Cytogenetic and Genome Research
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FCGR2A and FCGR3A Genotypes Correlate with Farletuzumab Response in Patients with First-Relapsed Ovarian Cancer Exhibiting Low CA125

2017 Cytogenetic and Genome Research
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