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Domenica Antonia Pizzi

GlaxoSmithKline

13

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185

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Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate

2011 Journal of Medicinal Chemistry
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Discovery and structure–activity relationship of a novel spirocarbamate series of NPY Y5 antagonists

2010 Bioorganic & Medicinal Chemistry Letters
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Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist.

2010 Journal of Medicinal Chemistry
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Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists.

2010 Bioorganic & Medicinal Chemistry Letters
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Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.

2009 Journal of Medicinal Chemistry
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Quinoline and quinazoline derivatives with affinity for receptors of the 5HT1 type

2004
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Synthesis and Antibacterial Activity of 4-Ureido Trinems.

1997 ChemInform
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Synthesis and antibacterial, activity of 4-ureido trinems

1996 Bioorganic & Medicinal Chemistry Letters
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Citations (7)