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Charles W. Hutchins

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Discovery and Optimization of Novel Constrained Pyrrolopyridone BET Family Inhibitors

2018 Bioorganic & Medicinal Chemistry Letters
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Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

2018 Protein & Cell
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Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists

2018 Bioorganic & Medicinal Chemistry Letters
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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

2017 Journal of Medicinal Chemistry
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Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides

2017 Journal of Medicinal Chemistry
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Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8

2016 ACS Medicinal Chemistry Letters
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S1P Lyase Bacterial Surrogate bound to N-(1-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)-2-((4-methoxy-2,5-dimethylbenzyl)amino)ethyl)-5-methylisoxazole-3-carboxamide

2016
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Creation of a S1P Lyase bacterial surrogate for structure-based drug design.

2016 Bioorganic & Medicinal Chemistry Letters
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Current status and future prospects for enabling chemistry technology in the drug discovery process

2016 F1000Research
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S1P Lyase Bacterial Surrogate bound to N-(2-((4-methoxy-2,5-dimethylbenzyl)amino)-1-phenylethyl)-5-methylisoxazole-3-carboxamide

2016
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