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G A Nickols

G. D. Searle & Company

4

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Peptidomimetic antagonists of alphavbeta3 inhibit bone resorption by inhibiting osteoclast bone resorptive activity, not osteoclast adhesion to bone.

2000 Journal of Endocrinology
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A peptidomimetic antagonist of the integrin αVβ3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy

1998 Cancer Research
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A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.

1997 Journal of Clinical Investigation
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Antibody to beta3 integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat

1996 Endocrinology
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