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Min Zheng

University of Florida

13

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571

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Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities.

2013 Anti-cancer Agents in Medicinal Chemistry
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Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

2013 BMC Cancer
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A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.

2013 Anti-cancer Agents in Medicinal Chemistry
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A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo

2012 Carcinogenesis
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Abstract #LB-10: Neurofibromin directly interacts with the N-terminal domain of Focal Adhesion Kinase

2009 Cancer Research
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A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

2009 Cell Cycle
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The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

2009 BMC Cancer
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Neurofibromin physically interacts with the N‐terminal domain of focal adhesion kinase

2009 Molecular Carcinogenesis
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Abstract #1926: A small-molecule inhibitor, targeting FAK and Mdm-2 interaction, blocks breast and colon tumorigenesis in vivo.

2009 Cancer Research
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A small molecule inhibitor 1,2,4,5-Benzenetetraamine tetrahydrochloride, targeting the Y397 site of Focal Adhesion Kinase decreases tumor growth

2008 Journal of Medicinal Chemistry
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