author-photo

Frank W. Byers

Vanderbilt University

26

Papers

528

Citations

Citation Trend

Filter By

Papers (19) Sort By

Journal Conference Others

Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

2018 Bioorganic & Medicinal Chemistry Letters
Show All
- Source
- Cite
- Save
Citations (3)
Corrigendum to “Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides” [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]

2018 Bioorganic & Medicinal Chemistry Letters
Show All
- Source
- Cite
- Save
Citations (0)
Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation

2017 Journal of Medicinal Chemistry
Show All
- Source
- Cite
- Save
Citations (21)
Optimization of M 4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology

2017 Bioorganic & Medicinal Chemistry Letters
Show All
- Source
- Cite
- Save
Citations (13)
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides

2017 Bioorganic & Medicinal Chemistry Letters
Show All
- Source
- Cite
- Save
Citations (12)
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

2017 Bioorganic & Medicinal Chemistry Letters
Show All
- Source
- Cite
- Save
Citations (7)
Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

2016 Drug Metabolism and Disposition
Show All
- Source
- Cite
- Save
Citations (12)
Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics

2015 Journal of Medicinal Chemistry
Show All
- Source
- Cite
- Save
Citations (17)
A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo

2015 Drug Metabolism and Disposition
Show All
- Source
- Cite
- Save
Citations (8)
Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2

2015 Journal of Medicinal Chemistry
Show All
- Source
- Cite
- Save
Citations (26)