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Annie Moisan

Hoffmann-La Roche

28

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1336

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Abstract LB066: Assessing the safety liability of t-cell bispecific (TCB) antibodies using Ogans-on-Chips technology

2021 Cancer Research
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Refining LNA safety profile by controlling phosphorothioate stereochemistry.

2020 PLOS ONE
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Developing in vitro Assays to Transform Gastrointestinal Safety Assessment: Potential for Microphysiological Systems

2020 Lab on a Chip
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High-throughput, perfused intestinal tubules for real-time assessment of drug-induced barrier disruption

2019 Drug Metabolism and Pharmacokinetics
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Deep neural networks predict drug-induced histopathology based on gene expression

2019 F1000Research
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GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells

2019 Molecular therapy. Nucleic acids
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Renal reabsorption in 3D vascularized proximal tubule models

2019 Proceedings of the National Academy of Sciences of the United States of America
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Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

2018 Drug Metabolism and Pharmacokinetics
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Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer

2018 Investigational New Drugs
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Mechanistic Investigations of Diarrhea Toxicity Induced by anti-HER2/3 Combination Therapy

2018 Molecular Cancer Therapeutics
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