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Alexander Alanine

Hoffmann-La Roche

57

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Peptidmakrocyclen gegen acinetobacter baumannii

2016
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Innentitelbild: Nahtlose Integration von Dosis‐Wirkungs‐basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur‐Aktivitäts‐Beziehungen von β‐Sekretase(BACE1)‐Hemmern (Angew. Chem. 6/2014)

2014 Angewandte Chemie
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Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors.

2014 Angewandte Chemie
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Nahtlose Integration von Dosis‐Wirkungs‐basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur‐Aktivitäts‐Beziehungen von β‐Sekretase(BACE1)‐Hemmern

2014 Angewandte Chemie
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Towards the enantioselective synthesis of (−)-euonyminol – preparation of a fully functionalised lower-rim model

2013 Organic and Biomolecular Chemistry
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Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels–Alder Reaction under Superheated Continuous Flow Conditions

2012 European Journal of Organic Chemistry
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An Ireland-ClaisenRearrangement/Lactonisation Cascade as a Key Step in StudiesTowards the Synthesis of (-)-Euonyminol:

2011 Synlett
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Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

2010 Journal of Medicinal Chemistry
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Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl] -4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist.

2010 ChemInform
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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration

2008 Bioorganic & Medicinal Chemistry Letters
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