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Alexander Goetz
Alexander Goetz
Technische Universität München
Transmembrane domain
Cleavage (embryo)
Biophysics
Mutant
Genetics
3
Papers
4
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0
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Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage
2018
bioRxiv
Alexander Goetz
Nadine Mylonas
Philipp Högel
Mara Silber
Hannes Heinel
Simon Menig
Alexander Vogel
Hannes Freyrer
Daniel Huster
Burkhard Luy
Dieter Langosch
Christina Scharnagl
Claudia Muhle-Goll
Frits Kamp
Harald Steiner
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Dissecting Conformational Changes in APP's Transmembrane Domain Linked to Altered ε-Efficiency of Familial Alzheimer's Disease Mutants
2018
bioRxiv
Alexander Goetz
Christina Scharnagl
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Stabilization / destabilization of the APP transmembrane domain by mutations in the di-glycine hinge alter helical structure and dynamics, and impair cleavage by γ-secretase
2018
bioRxiv
Alexander Goetz
Nadine Mylonas
Philipp Hoegel
Mara Silber
Hannes Heinel
Simon Menig
Alexander Vogel
Hannes Freyrer
Daniel Huster
Burkhard Luy
Dieter Langosch
Christina Scharnagl
Claudia Muhle-Goll
Frits Kamp
Harald Steiner
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Citations (3)
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