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Kengo Watanabe

Daiichi Sankyo

10

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The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models

2019 Nature Communications
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Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives.

2018 Bioorganic & Medicinal Chemistry Letters
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Synthesis and SAR studies of 3,6-disubstituted indazole derivatives as potent hepcidin production inhibitors

2017 Bioorganic & Medicinal Chemistry Letters
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Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives

2017 Bioorganic & Medicinal Chemistry Letters
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Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties

2009 Bioorganic & Medicinal Chemistry
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Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 Binding Element

2004 Journal of Medicinal Chemistry
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