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Gwen A. Morgan

14

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Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents

2009 Bioorganic & Medicinal Chemistry Letters
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Discovery of (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid Hydrochloride (GAP-134)13, an Orally Active Small Molecule Gap-Junction Modifier for the Treatment of Atrial Fibrillation

2009 Journal of Medicinal Chemistry
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GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs.

2009 Journal of Cardiovascular Pharmacology and Therapeutics
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The Gap Junction Modifier, GAP-134 [(2S,4R)-1-(2-Aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic Acid], Improves Conduction and Reduces Atrial Fibrillation/Flutter in the Canine Sterile Pericarditis Model

2009 Journal of Pharmacology and Experimental Therapeutics
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Effect of tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis

2008 Journal of Thrombosis and Haemostasis
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Abstract 1837: Effects of the Gap Junction Modifier, GAP-134, on Conduction and Atrial Fibrillation/Flutter Inducibility in Dogs

2007 Circulation
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Pharmacologic inhibition of platelet vWF-GPIbα interaction prevents coronary artery thrombosis

2006 Thrombosis and Haemostasis
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ID: 190 Efficacy of PAI-749, an orally active PAI-1 inhibitor, in dog and rat models of arterial and venous thrombosis

2006 Journal of Thrombosis and Haemostasis
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Evaluation of PAI-039 [{1-Benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic Acid], a Novel Plasminogen Activator Inhibitor-1 Inhibitor, in a Canine Model of Coronary Artery Thrombosis

2005 Journal of Pharmacology and Experimental Therapeutics
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Evaluation of PAI-039, a Novel PAI-1 Inhibitor, in a Canine Model of Coronary Artery Thrombosis

2005 Journal of Pharmacology and Experimental Therapeutics
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