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Richard William Arthur Luke

AstraZeneca

45

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Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background

2012 Molecular Cancer Therapeutics
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Abstract 4478: Discovery of AZD5363, an orally bioavailable, potent ATP-competitive inhibitor of AKT kinases

2011 Cancer Research
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Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor

2009
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Abstract C208: CCT129254 (AT11854) is a well tolerated, orally bioavailable inhibitor of AKT/PKB with pharmacodynamic and antitumor activity in a range of xenograft models

2009 Molecular Cancer Therapeutics
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Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.

2009 Bioorganic & Medicinal Chemistry Letters
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Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.

2008 Bioorganic & Medicinal Chemistry Letters
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Composes possedant une activite inhibitrice de tie2 (tek)

2006
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Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

2005 Journal of Medicinal Chemistry
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Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor

2004 Structure
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Nouveaux heterocycles fusionnes et leurs utilisations

2004
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