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James P. Lees-Miller

University of Calgary

30

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1048

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Structural insights into the role of DNA-PK as a master regulator in NHEJ

2021
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Lipid regulation of hERG1 channel function.

2021 Nature Communications
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Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease

2020 Progress in Biophysics & Molecular Biology
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Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade

2020 Frontiers in Pharmacology
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Role of the pH in state-dependent blockade of hERG currents.

2016 Scientific Reports
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Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4

2015 Journal of Molecular and Cellular Cardiology
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Role of Mutation and Pharmacologic Block of hERG (KCNH2) in Vasculogenesis and Fetal Mortality: Partial Rescue by TGFβ

2015 Circulation-arrhythmia and Electrophysiology
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Role of Mutation and Pharmacologic Block of Human KCNH2 in Vasculogenesis and Fetal Mortality: Partial Rescue by Transforming Growth Factor-β

2015 Circulation-arrhythmia and Electrophysiology
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In response to Melgari et al. “hERG potassium channel inhibition by ivabradine requires channel gating”

2015 Journal of Molecular and Cellular Cardiology
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NS1643 Interacts around L529 of hERG to Alter Voltage Sensor Movement on the Path to Activation

2015 Biophysical Journal
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Citations (23)