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Sudhir Rao

Merck & Co.

9

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835

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Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

2012 Journal of Experimental Medicine
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Abstract 3394: A gamma secretase inhibitor reduces large neurosphere formation in glioma cell lines which correlates with decreased tumorigenicity

2011 Cancer Research
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Abstract C249: Down-regulation of the HIF pathway enhances anti-tumor effects of the mTOR inhibitor ridaforolimus in the Her2/Neu mouse model of breast cancer

2009 Molecular Cancer Therapeutics
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Down-regulation of the Notch pathway mediated by a γ-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia

2009 British Journal of Pharmacology
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RESEARCH PAPER Down-regulation of the Notch pathway mediated by a g-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia

2009
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Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

2009 Cancer Research
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A putative stemness biomarker gene set suggests γ-secretase inhibitor targets self-renewal and pluripotency programs in tumors

2008 Clinical Cancer Research
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Targeting Notch in cancer with gamma-secretase inhibitors

2007 Molecular Cancer Therapeutics
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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

2007 Journal of Experimental Medicine
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