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Lennart Lindfors

AstraZeneca

38

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Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

2021 Molecular therapy. Nucleic acids
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Time evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA

2021 bioRxiv
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Screening of the binding affinity of serum proteins to lipid nanoparticles in a cell free environment.

2021 Journal of Colloid and Interface Science
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Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles.

2021 ACS Nano
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Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

2020 bioRxiv
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Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

2019 Nature Communications
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Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation

2019 Journal of Controlled Release
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Atomistic Modeling of Drug Permeability

2019
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Nanocrystal formulations of a poorly soluble drug. 1. In vitro characterization of stability, stabilizer adsorption and uptake in liver cells

2017 International Journal of Pharmaceutics
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Nanocrystal formulations of a poorly soluble drug. 2. Evaluation of nanocrystal liver uptake and distribution after intravenous administration to mice.

2017 International Journal of Pharmaceutics
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