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Fredrik Jeppsson

AstraZeneca

27

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AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

2016 Journal of Alzheimer's Disease
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Altered amyloid PET ligand binding to ApoE-containing plaques in Alzheimer´s disease brain in vitro

2016
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Population PKPD modeling of BACE1 inhibitor-induced reduction in Aβ levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.

2014 Pharmaceutical Research
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Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer’s disease patients

2013 European Journal of Nuclear Medicine and Molecular Imaging
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AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

2013 The Journal of Neuroscience
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New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain.

2012 Journal of Medicinal Chemistry
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The performance of Aβ5-X isoforms as novel pharmacodynamic markers of BACE1 inhibition

2012 Alzheimers & Dementia
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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer

2012
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Preclinical characterization of AZD3839, a novel clinical candidate BACE1 inhibitor for the treatment of Alzheimer Disease

2012
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Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides.

2012 Journal of Medicinal Chemistry
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Citations (69)