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Katja S. Kroker

Boehringer Ingelheim

18

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S31. ENHANCEMENT OF SYNAPTIC PLASTICITY BY COMBINATION OF PDE2 AND PDE9 INHIBITION PRESUMABLY VIA PRE- AND POST-SYNAPTIC MECHANISMS

2020 Schizophrenia Bulletin
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sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling

2018 Experimental Neurology
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Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice.

2018 PLOS ONE
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Role of PDE9 in Cognition

2017 Advances in neurobiology
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Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression

2017 Alzheimer's Research & Therapy
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Age-related synaptic dysfunction in Tg2576 mice starts as a failure in early long-term potentiation which develops into a full abolishment of late long-term potentiation

2016 Journal of Neuroscience Research
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Pathophysiological Toolkit; Genes to Circuits

2015
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PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition.

2014 Neurobiology of Aging
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RESTORING LONG-TERM POTENTIATION IMPAIRED BY AMYLOID-BETA OLIGOMERS: COMPARISON OF A BROADLY-SPECIFIC ANTI AMYLOID-BETA NANOBODY AND A MONOMER-SPECIFIC ANTIBODY

2014 Alzheimers & Dementia
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Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists.

2013 Brain Research Bulletin
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