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Jay Groppe

Texas A&M University

45

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3358

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Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification

2018 Bone
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Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

2016 Journal of Bone and Mineral Research
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Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3

2013 Nature Medicine
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Functional Analysis of Alleged NOGGIN Mutation G92E Disproves Its Pathogenic Relevance

2012 PLOS ONE
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Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice

2012 PLOS Genetics
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In vitro Analyses of the Dysregulated R206H ALK2 Kinase-FKBP12 Interaction Associated with Heterotopic Ossification in FOP

2011 Cells Tissues Organs
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Identification of a core domain within the proregion of bone morphogenetic proteins that interacts with the dimeric, mature domain.

2011 Biochemical and Biophysical Research Communications
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The TβR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding

2011 Journal of Molecular Biology
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Fibrodysplasia Ossificans Progressiva: Developmental Implications of a Novel Metamorphogene

2010
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Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN

2009 PLOS Genetics
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Citations (81)