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Roger John Butlin

AstraZeneca

35

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Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1

2013 MedChemComm
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A Mild Benzannulation Through Directed Cycloaddition Reactions.

2012 ChemInform
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Stereoselective Approaches to 2,3,6-Trisubstituted Piperidines. An Enantiospecific Synthesis of Quinolizidine (-)-217A (XI)

2012 ChemInform
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Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.

2012 Journal of Medicinal Chemistry
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A Mild Benzannulation through Directed Cycloaddition Reactions

2012 Angewandte Chemie
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Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).

2012 Journal of Medicinal Chemistry
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Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

2012 Bioorganic & Medicinal Chemistry Letters
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Discovery, optimisation and in vivo evaluation of novel GPR119 agonists

2011 Bioorganic & Medicinal Chemistry Letters
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Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

2011 Bioorganic & Medicinal Chemistry Letters
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Carboxamides de pyrazine utiles comme inhibiteurs de la dgat1

2010
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