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Amy E. Chadwick

University of Liverpool

27

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406

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Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers.

2021 Archives of Toxicology
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Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models.

2021 Toxicology in Vitro
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The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review.

2021 Frontiers in Genetics
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The mitochondrial paradox.

2020 eLife
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Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity

2019 Current protocols in immunology
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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

2019 Nature Reviews Drug Discovery
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Modelling changes in glutathione homeostasis as a function of quinone redox metabolism

2019 Scientific Reports
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In silico-guided optimisation of oxygen gradients in hepatic spheroids

2019 Computational Toxicology
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Evaluating Mitotoxicity as Either a Single or Multi-Mechanistic Insult in the Context of Hepatotoxicity

2018
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Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon bioenergetic function and susceptibility to hepatotoxicity

2018 Biochimica et Biophysica Acta
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