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R. Mathew Thomas

ARIAD Pharmaceuticals, Inc.

13

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379

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Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery

2016 Journal of Medicinal Chemistry
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Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.

2013 Journal of Medicinal Chemistry
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Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.

2010 Journal of Medicinal Chemistry
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Dérivés phosphorés servant d'inhibiteurs de kinase

2009
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Composes d'heteroaryle monocyclique

2007
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Facile synthesis of 9-(arenethenyl)purines via Heck reaction of 9-vinylpurines and aryl halides

2007 Tetrahedron Letters
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Bicyclische heteroaryl-verbindungen

2006
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Composes heteroaryles bicycliques acetyleniques utiles comme inhibiteurs de kinase

2006
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Heteroaryl bicyclic compounds

2006
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Chirally modified NaBH 4 /ZrCl 4 promoted asymmetric reduction of prochiral ketones †

2000
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