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Qingzhong Hu

Saarland University

43

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Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing’s Disease

2017 Journal of Medicinal Chemistry
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Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis

2016 Journal of Medicinal Chemistry
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Targeting Steroidogenic Cytochromes P450 (CYPs) with 6-Substituted 1-Imidazolylmethylxanthones

2016 ChemMedChem
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Specificity of anti-prostate cancer CYP17A1 inhibitors on androgen biosynthesis

2016 Biochemical and Biophysical Research Communications
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Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11β-Hydroxylase.

2015 European Journal of Medicinal Chemistry
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Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase

2015 European Journal of Medicinal Chemistry
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Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

2015 ACS Medicinal Chemistry Letters
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1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: A new class of potent and selective aldosterone synthase inhibitors

2015 European Journal of Medicinal Chemistry
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Aldosterone Synthase Inhibitors as Promising Treatments for Mineralocorticoid Dependent Cardiovascular and Renal Diseases

2014 Journal of Medicinal Chemistry
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Potent 11β-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing.

2014 Journal of Medicinal Chemistry
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