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Christopher M. Flores

Janssen Pharmaceutica

20

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408

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Application of Real-World Data and the REWARD Framework to Detect Unknown Benefits of Memantine and Identify Potential Disease Targets for New NMDA Receptor Antagonists.

2021 CNS Drugs
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The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors

2020 Bioorganic & Medicinal Chemistry Letters
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Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model.

2020 Neurobiology of Pain
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The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL).

2020 Bioorganic & Medicinal Chemistry Letters
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Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor.

2019 Journal of Pharmacology and Experimental Therapeutics
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A multiple-dose double-blind randomized study to evaluate the safety, pharmacokinetics, pharmacodynamics and analgesic efficacy of the TRPV1 antagonist JNJ-39439335 (mavatrep)

2018 Scandinavian Journal of Pain
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Characterization of the trigeminovascular actions of several adenosine A 2A receptor antagonists in an in vivo rat model of migraine

2018 Journal of Headache and Pain
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Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain

2018 Bioorganic & Medicinal Chemistry Letters
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A randomized study to evaluate the analgesic efficacy of a single dose of the TRPV1 antagonist mavatrep in patients with osteoarthritis

2017 Scandinavian Journal of Pain
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Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity

2015 Journal of Lipid Research
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Citations (42)