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Karolina Madela

Cardiff University

16

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363

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Phosphorodiamidates as a Promising New Phosphate Prodrug Motif for Antiviral Drug Discovery: Application to Anti-HCV Agents

2011 Journal of Medicinal Chemistry
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Dual pro-drugs of 2 '-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus

2011 Bioorganic & Medicinal Chemistry Letters
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INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties

2011 Antimicrobial Agents and Chemotherapy
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Nucléosides puriques substitués, dérivés phosphoramidate et phosphorodiamidate pour le traitement d'infections virales

2011
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Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

2010 Journal of Medicinal Chemistry
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Phosphoramidate Protides Greatly Enhance the Anti-HCV Activity of 2′-Methylguanosine

2009 Antiviral Research
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969 CHARACTERIZATION OF A SERIES OF HIGHLY POTENT PHOSPHORAMIDATE NUCLEOSIDE ANALOGUE INHIBITORS OF HEPATITIS C POLYMERASE

2009 Journal of Hepatology
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In Vitro Activity and In Vivo Pharmacokinetics of Highly Potent Phosphoramidate Nucleoside Analogue Inhibitors of Hepatitis C NS5B

2009 Antiviral Research
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The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus

2009 Bioorganic & Medicinal Chemistry Letters
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Citations (38)