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Christopher Houle

Pfizer

22

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358

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Publication Categories in Toxicologic Pathology

2021 Toxicologic Pathology
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An in vitro alveolar epithelial cell model recapitulates LRRK2 inhibitor-induced increases in lamellar body size observed in preclinical models

2020 Toxicology in Vitro
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LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

2020 Science Translational Medicine
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LRRK2 kinase inhibitors induce a reversible effect in the lungs of non-human primates with no measurable pulmonary deficits

2018 bioRxiv
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Spontaneous Ectopic Choroid Plexus with Sclerosis in Adult Beagle Dogs

2018 Toxicologic Pathology
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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation

2018 Journal of Medicinal Chemistry
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Use of Rat Primary Mesenteric Cells for the Prediction of PDE4 Inhibitor Drug-Induced Vascular Injury.

2017 Toxicological Sciences
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Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators

2017 Chemistry & Biology
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INHIBITION OF BACE2 AFFECTS MELANOSOME ULTRASTRUCTURE AND CAUSES OF HYPOPIGMENTATION

2016 Alzheimers & Dementia
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Age-related testicular toxicity of mGluR5 negative allosteric modulators appears to be unrelated to testis drug transporter maturity.

2015 Reproductive Toxicology
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