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Michael D. Spengler
Michael D. Spengler
GlaxoSmithKline
Biochemistry
Structure–activity relationship
Phosphatidylinositol
Kinase
Growth inhibition
5
Papers
150
Citations
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[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors.
2013
ACS Medicinal Chemistry Letters
Hongyi Yu
Michael L. Moore
Karl F. Erhard
Mary Ann Hardwicke
Hong Lin
Juan I. Luengo
Jeanelle McSurdy-Freed
Ramona Plant
Junya Qu
Kaushik Raha
Cynthia M. Rominger
Michael D. Schaber
Michael D. Spengler
Ralph A. Rivero
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Citations (13)
Synthesis and structure–activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors
2012
Bioorganic & Medicinal Chemistry Letters
Robert M. Sanchez
Karl F. Erhard
Mary Ann Hardwicke
Hong Lin
Jeanelle McSurdy-Freed
Ramona Plant
Kaushik Raha
Cynthia M. Rominger
Michael D. Schaber
Michael D. Spengler
Michael L. Moore
Hongyi Yu
Juan I. Luengo
Rosanna Tedesco
Ralph A. Rivero
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Citations (39)
Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.
2012
Bioorganic & Medicinal Chemistry Letters
Hong Lin
Karl F. Erhard
Mary Ann Hardwicke
Juan I. Luengo
James F. Mack
Jeanelle McSurdy-Freed
Ramona Plant
Kaushik Raha
Cynthia M. Rominger
Robert M. Sanchez
Michael D. Schaber
Mark J. Schulz
Michael D. Spengler
Rosanna Tedesco
Ren Xie
Jin J. Zeng
Ralph A. Rivero
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Citations (37)
Enhancement of in vitro and in vivo microdialysis recovery of SB-265123 using Intralipid and Encapsin as perfusates.
2003
Biopharmaceutics & Drug Disposition
Keith W. Ward
Sarah J. Medina
Samm T. Portelli
Kelly M. Mahar Doan
Michael D. Spengler
Michael M. Ben
David Lundberg
Mark A. Levy
Emile P. Chen
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Citations (31)
1