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Dag Sehlin

Uppsala University

72

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1251

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Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain

2021 Theranostics
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Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size.

2021 Fluids and Barriers of the CNS
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In vivo imaging of synaptic density with [ 11 C]UCB-J PET in two mouse models of neurodegenerative disease

2021 NeuroImage
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11C-PIB and 124I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention.

2021 The Journal of Nuclear Medicine
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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.

2021 Science Translational Medicine
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Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease.

2021 Molecular Imaging and Biology
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Development of Trans-Cyclooctene Modified Antibodies for Pretargeted Imaging within the Central Nervous System

2020 The Journal of Nuclear Medicine
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Extracellular vesicles from amyloid-β exposed cell cultures induce severe dysfunction in cortical neurons.

2020 Scientific Reports
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Engineered antibodies: new possibilities for brain PET?

2019 European Journal of Nuclear Medicine and Molecular Imaging
- Dag Sehlin
- Stina Syvänen
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Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology

2019 Journal of Biological Chemistry
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