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Yujie Li

Discovery Institute

16

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Table 3, Summary of in vitro ADME Properties of UPR CHOP Activator probe ML291

2013
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Discovery of ML314, a Brain Penetrant Nonpeptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor

2013 ACS Medicinal Chemistry Letters
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Figure A6D, HRMS data for ML291 1st batch (SID 123083137, CID 52940465); HRMS m/z calculated for C16H17ClN3O6S [M + H+]: 414.0521, found 414.0527

2013
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Figure 3, Activation of luciferase reporters driven by UPR sub-pathway promoters for the apoptotic (CHOP) and adaptive (XBP1) arms

2013
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Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists)

2013
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[Table], EXPERIMENTAL RESULTS FOR SID 123083137 ON OTHER TARGETS

2013
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Figure A6C, LCMS purity data at 214 nm for ML291 1st batch (SID 123083137, CID 52940465); LCMS retention time: 3.074 min; purity at 214 nm = 95.4%

2013
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Selective small molecule activator of the apoptotic arm of the UPR

2013
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Figure 2, Chemical stability of ML291, represented by percent of parent remaining over time, in the presence of five-fold molar equivalent of GSH or DTT, incubated at room temperature in 1:1 ACN:PBS, pH 7.4, 1% (v/v) DMSO

2013
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