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Elena Fossati
Elena Fossati
Université de Montréal
Dihydrofolate reductase
Biochemistry
Molecular biology
Enzyme
Biology
4
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86
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Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells
2011
Journal of Molecular Recognition
Jordan P. Volpato
Nadine Mayotte
Elena Fossati
Vanessa Guerrero
Guy Sauvageau
Joelle N. Pelletier
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Citations (6)
Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance
2009
Journal of Biological Chemistry
Jordan P. Volpato
Brahm J. Yachnin
Jonathan Blanchet
Vanessa Guerrero
Lucie Poulin
Elena Fossati
Albert M. Berghuis
Joelle N. Pelletier
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Citations (33)
2-Tier Bacterial and In Vitro Selection of Active and Methotrexate-Resistant Variants of Human Dihydrofolate Reductase
2008
Journal of Biomolecular Screening
Elena Fossati
Jordan P. Volpato
Lucie Poulin
Vanessa Guerrero
David-Antoine Dugas
Joelle N. Pelletier
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Citations (15)
Increasing Methotrexate Resistance by Combination of Active-site Mutations in Human Dihydrofolate Reductase
2007
Journal of Molecular Biology
Jordan P. Volpato
Elena Fossati
Joelle N. Pelletier
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Citations (32)
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