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Cristiana Guiducci

University of California, Berkeley

46

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Nx-5948, a Selective Degrader of BTK with Activity in Preclinical Models of Hematologic and Brain Malignancies

2021 Blood
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Abstract 1595: Small molecule inhibition of the ubiquitin ligase CBL-B results in potent T and NK cell mediated anti-tumor response

2021 Immunology
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Abstract 2259: Tumor abscopal responses induced by the TLR9 agonist, SD-101, are strongly potentiated by a HDAC class I inhibitor, domatinostat

2019 Cancer Research
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Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T-cell Interplay

2018 Cancer Research
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Abstract 5596: Intratumoral administration of a TLR9-adjuvanted nanoparticle cancer vaccine stimulates more effective immunity in both injected and un-injected tumor sites compared to subcutaneous administration

2017 Cancer Research
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ADMINISTRATION INTRATUMORALE DE PARTICULES CONTENANT UN AGONISTE DU RÉCEPTEUR TOLL 9 ET UN ANTIGÈNE TUMORAL POUR LE TRAITEMENT DU CANCER

2017
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Abstract LB-239: Pharmacodynamic changes confirm the mechanism of action mediating SD-101 efficacy, in combination with pembrolizumab, in a phase 1b/2 study in metastatic melanoma (MEL-01)

2017 Cancer Research
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Abstract 4696: Development of an inhaled TLR9 agonist for the immunotherapy of lung cancer

2017 Cancer Research
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Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer

2017 JCI insight
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Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

2017 The Journal of Allergy and Clinical Immunology
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