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David Moreno

18

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Composés de pyrazolo[1,5-a]pyrazine substitués utilisés en tant qu'inhibiteurs de la kinase ret

2018
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Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

2016 Journal of Medicinal Chemistry
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Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.

2015 Journal of Medicinal Chemistry
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Abstract DDT02-03: Discovery of GDC-0994, a potent and selective ERK1/2 inhibitor in early clinical development

2014 Cancer Research
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Composés de quinazoline utiles en tant qu'inhibiteurs de la sérine/thréonine kinase

2012
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Pyrazolopyridine inhibitors of B-RafV600E. Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors

2012 Bioorganic & Medicinal Chemistry Letters
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The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase

2012 Bioorganic & Medicinal Chemistry Letters
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Pyrazolopyridine inhibitors of B-RafV600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing

2012 Bioorganic & Medicinal Chemistry Letters
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Sulfonamides hétérocycliques en tant qu'inhibiteurs de raf

2011
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Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.

2011 Bioorganic & Medicinal Chemistry Letters
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Citations (46)