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Nicholas J. Izzo

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Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein.

2021 Journal of Neuroscience Research
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In vivo evaluation of carbon-11 labeled 6,7-dimethoxy-1,2,3,4-tetrahydroinsoquinoline derivatives (11C-4-MPTHQ) for potential use as σ2R brain PET tracer

2021 Nuclear Medicine and Biology
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The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease.

2020 Alzheimer's Research & Therapy
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Proceedings from the fourth international symposium on sigma-2 receptors: Role in health and disease

2020
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A PHASE 1 SAFETY TRIAL OF THE Aβ OLIGOMER RECEPTOR ANTAGONIST CT1812

2017 Alzheimers & Dementia
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A TWO-PART, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 1 STUDY OF THE SAFETY AND PHARMACOKINETICS OF SINGLE AND MULTIPLE ASCENDING DOSES OF CT1812 IN HEALTHY VOLUNTEERS

2016 Alzheimers & Dementia
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Alzheimer's Therapeutics Targeting Amyloid Beta 1-42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

2014 PLOS ONE
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An Abeta Oligomer Receptor Antagonist and Antibodies to Specific Target Receptor Epitopes Displace Abeta Oligomers in Alzheimer’s Patient Brain Tissue Sections (I11-1.001)

2014 Neurology
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Compositions et méthodes pour le traitement de maladies neurodégénératives

2012
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Novel Anti-oligomer Compounds Stop Memory Deficits

2010 Alzheimers & Dementia
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