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Nyree Crawford

Queen's University Belfast

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Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC)

2021 bioRxiv
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Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.

2021 Molecular Cancer Therapeutics
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Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC).

2021 Gut
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Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant.

2020 Cell Death and Disease
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The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

2020 Proceedings of the National Academy of Sciences of the United States of America
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A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

2020 EMBO Reports
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Clinical positioning of the IAP antagonist tolinapant (ASTX660) in colorectal cancer

2020 bioRxiv
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Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer

2020 Cell death discovery
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The SCF Skp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

2020 Cell Death & Differentiation
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DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models.

2020 Journal of Controlled Release
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