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Maria Josè Ruiz Alvarez

Istituto Superiore di Sanità

11

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Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-Cells and improves immune function in subjects on HAART (Phase II ISS T-002)

2011
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Phase I preventative clinical trial with the Tat vaccine (ISS P-001) and long term follow-up

2011
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Therapeutic immunization with hiv-1 tat reduces immune activation and loss of regulatory t-cells and improves immune function in subjects on HAART

2010 PLOS ONE
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Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up

2009 Vaccine
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Anti-Tat humoral and cellular immunity in HIV-1 infected patients, including asymptomatic individuals and LTNP, aimed at identifying immune correlates of protection which are key to vaccine development

2006
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Analysis of anti-Tat humoral immunity in HIV-1 infected patients, including LTNP individuals, aimed at identifying immune correlates of protection which are key to vaccine development

2006
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Prophylactic and therapeutic phase I trials with the active Tat protein vaccine: results of the interim analysis

2006
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Anti-Tat specific immune response in human natural model of resistance to infection such as multiply exposed uninfected individuals (MEU)

2005
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Immunological and virological background studies according to the specific vaccine candidate to be tested in phase I/II clinical trials

2005
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