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Hongxing Yan

GlaxoSmithKline

17

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287

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Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo

2019 Bioorganic & Medicinal Chemistry
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Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-associated protein 1 : Nuclear factor erythroid 2–related factor 2 (KEAP1:NRF2) protein-protein interaction

2019 Journal of Medicinal Chemistry
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Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

2016 Journal of Medicinal Chemistry
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Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.

2016
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Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study

2014 Analyst
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Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

2012 Bioorganic & Medicinal Chemistry Letters
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Pde4-muscarin-antagonisten-doppelpharmacophoren

2009
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Pharmacophores duals, antagonistes des récepteurs muscariniques et inhibiteurs de l'activité pde4

2009
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Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1 ]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

2009 Bioorganic & Medicinal Chemistry Letters
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Design, Synthesis, and Structure-Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists

2009 Journal of Medicinal Chemistry
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