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Margaret M. Zaleska

Pfizer

11

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270

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Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models

2016 Neuron
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J19 Paving the way for a Promising PDE10 drug with an Enzyme Occupancy Study, A 28 Day Safety Study Assessing Corticostriatal Activity and a 6 Month Safety and Efficacy Study in HD Patients

2014 Journal of Neurology, Neurosurgery, and Psychiatry
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Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease

2013 PLOS ONE
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Long‐lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP‐ribose) polymerase

2012 British Journal of Pharmacology
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The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid.

2011 Neuropharmacology
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Assessment of PF-04995274 in scopolamine-disrupted Morris water maze compared to and in combination with donepezil

2011 Alzheimers & Dementia
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Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ

2011 MedChemComm
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Use of Ethological Rodent Behavior to Assess Efficacy of Potential Drugs for Alzheimer's Disease

2010
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