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Michino Murakami
Michino Murakami
Mitsubishi Tanabe Pharma
cGMP-specific phosphodiesterase type 5
Chemistry
Biochemistry
highly selective
Isozyme
2
Papers
28
Citations
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The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor.
2014
Bioorganic & Medicinal Chemistry Letters
Toshiaki Sakamoto
Yuichi Koga
Masataka Hikota
Kenji Matsuki
Michino Murakami
Kohei Kikkawa
Kotomi Fujishige
Jun Kotera
Kenji Omori
Hiroshi Morimoto
Koichiro Yamada
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Citations (17)
Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: Scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation
2014
Bioorganic & Medicinal Chemistry Letters
Toshiaki Sakamoto
Yuichi Koga
Masataka Hikota
Kenji Matsuki
Michino Murakami
Kohei Kikkawa
Kotomi Fujishige
Jun Kotera
Kenji Omori
Hiroshi Morimoto
Koichiro Yamada
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Citations (11)
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