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Joseph Grimsby

AstraZeneca

8

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53

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Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease.

2021 Scientific Reports
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LEGACY: Phase 2a Trial to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamic Effects of the Anti-EL (Endothelial Lipase) Antibody MEDI5884 in Patients With Stable Coronary Artery Disease

2021 Arteriosclerosis, Thrombosis, and Vascular Biology
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Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial.

2021 Science Translational Medicine
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Differences in levels of phosphatidylinositols in healthy and stable Coronary Artery Disease subjects revealed by HILIC-MRM method with SERRF normalization.

2021 PLOS ONE
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Peptide-YY3-36/Glucagon-Like Peptide-1 Combination Treatment of Obese-Diabetic Mice Improves Insulin Sensitivity associated with Recovered Pancreatic ß-Cell Function and Synergistic Activation of Discrete Hypothalamic and Brainstem Neuronal Circuitries.

2021 Molecular metabolism
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Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

2020
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LOX-1: A potential driver of cardiovascular risk in SLE patients.

2020 PLOS ONE
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