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Giovanni Germano

University of Turin

37

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3327

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Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers.

2021 Cancers
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T cells expressing receptor recombination/revision machinery are detected in the tumor microenvironment and expanded in genomically over-unstable models.

2021 Cancer immunology research
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CD4 T cell dependent rejection of beta 2 microglobulin null mismatch repair deficient tumors.

2021 Cancer Discovery
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High-dose vitamin C enhances cancer immunotherapy

2020 Science Translational Medicine
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SP-0453 Targeting DNA repair to improve immunesurveillance and restrict cancer growth

2019 Radiotherapy and Oncology
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Pembrolizumab in MMR-proficient metastatic colorectal cancer pharmacologically primed to trigger dynamic hypermutation status: The ARETHUSA trial.

2019 Journal of Clinical Oncology
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Abstract CT215: Pharmacological inactivation of DNA repair to improve response to immunotherapy: The Arethusa trial in metastatic colorectal cancer

2019 Clinical Trials
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Inactivation of DNA repair—prospects for boosting cancer immune surveillance

2018 Genome Medicine
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PO-332 Genomic landscapes, neoantigen profiles and biological impact of mlh1 inactivation in cancer cells

2018
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Abstract 5723: Inactivation of DNA repair triggers neoantigen generation and impairs tumor growth

2018 Cancer Research
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