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Christopher Bebbington

Corixa Corporation

44

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A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation.

2020 Mucosal Immunology
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Siglec-8 antibody reduces eosinophil and mast cell infiltration in a transgenic mouse model of eosinophilic gastroenteritis

2019 JCI insight
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Mo1163 – Eg and Eoe Patient Biopsies Have High Numbers of Activated Eosinophils and Mast Cells that are Inhibited by Ak002

2019 Gastroenterology
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AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice

2019 International Archives of Allergy and Immunology
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352 - AK002, a First-in-Class, Humanized, Non-Fucosylated IGG1 Siglec-8 Antibody, Selectively Depletes Blood and Tissue Eosinophils

2018 Gastroenterology
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Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

2018 The Journal of Allergy and Clinical Immunology
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A Randomized, Double-Blind, Placebo-Controlled, Ascending Dose Phase 1 Study of AK002, a Novel Siglec-8 Selective Monoclonal Antibody, in Healthy Subjects

2018 The Journal of Allergy and Clinical Immunology
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Marley the Adventurer: Captain Logan the Pirate by christopher Bebbington Action & Adventure

2017
- Christopher Bebbington
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Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis

2016 The Journal of Allergy and Clinical Immunology
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A Recombinant Antibody to Siglec-8 Shows Selective ADCC Activity Against Mast Cells from Systemic Mastocytosis Patients

2015 Blood
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