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Norman C. W. Wong

University of Calgary

174

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Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro

2021 Biomedicines
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Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-CoV-2 Infection in vitro

2021 bioRxiv
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Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial.

2021 Cardiovascular Diabetology
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Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome: Results from the BETonMACE Randomized Controlled Trial.

2021 Clinical Journal of The American Society of Nephrology
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MO072APABETALONE DOWNREGULATES FIBROTIC, INFLAMMATORY AND CALCIFIC PROCESSES IN RENAL MESANGIAL CELLS WHICH MAY CONTRIBUTE TO REDUCED CARDIAC EVENTS OBSERVED IN CKD PATIENTS

2021 Nephrology Dialysis Transplantation
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Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial.

2021 Journal of Alzheimer's Disease
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BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.

2021 Cell
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Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

2021 bioRxiv
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APABETALONE (RVX-208) REDUCES ACE2 PROTEIN ABUNDANCE AND PREVENTS SARS-COV-2 SPIKE PROTEIN BINDING TO HUMAN LUNG CELLS, A MOA THAT COULD ATTENUATE VIRAL ENTRY

2021 Journal of the American College of Cardiology
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EPIGENETIC BET READER INHIBITOR APABETALONE (RVX-208) COUNTERS PROINFLAMMATORY AORTIC GENE EXPRESSION IN A DIET INDUCED OBESITY MOUSE MODEL

2021 Journal of the American College of Cardiology
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