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Hilary B. Schock

United States Military Academy

4

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An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.

2000 Acta Crystallographica Section D-biological Crystallography
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NON-ACTIVE SITE CHANGES ELICIT BROAD-BASED CROSS-RESISTANCE OF THE HIV-1 PROTEASE TO INHIBITORS

1999 Journal of Biological Chemistry
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Mutational Anatomy of an HIV-1 Protease Variant Conferring Cross-resistance to Protease Inhibitors in Clinical Trials COMPENSATORY MODULATIONS OF BINDING AND ACTIVITY

1996 Journal of Biological Chemistry
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Three-dimensional Structure of a Mutant HIV-1 Protease Displaying Cross-resistance to All Protease Inhibitors in Clinical Trials

1995 Journal of Biological Chemistry
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