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Allison Oberholtzer
Allison Oberholtzer
Janssen Pharmaceutica
Antibody
Effector
Biology
Proteases
Molecular biology
3
Papers
149
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A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy
2012
Breast Cancer Research
Xuejun Fan
Randall J. Brezski
Ming Fa
Hui Deng
Allison Oberholtzer
Anneliese Gonzalez
William P. Dubinsky
William R. Strohl
Robert E. Jordan
Ningyan Zhang
Zhiqiang An
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Citations (49)
The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge.
2011
mAbs
Randall J. Brezski
Allison Oberholtzer
Brandy Strake
Robert E. Jordan
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Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge.
2009
Proceedings of the National Academy of Sciences of the United States of America
Randall J. Brezski
Omid Vafa
Diane Petrone
Susan H. Tam
Gordon Powers
Mary Ryan
Jennifer L. Luongo
Allison Oberholtzer
David M. Knight
Robert E. Jordan
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Citations (70)
1