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Francesca Necchi

Novartis

40

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706

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Efficacy, safety, and immunogenicity of the Shigella sonnei 1790GAHB GMMA candidate vaccine: Results from a phase 2b randomized, placebo-controlled challenge study in adults.

2021 EClinicalMedicine
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Development of a Monocyte Activation Test as an Alternative to the Rabbit Pyrogen Test for Mono- and Multi-Component Shigella GMMA-Based Vaccines.

2021
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Novel Simple Conjugation Chemistries for Decoration of GMMA with Heterologous Antigens

2021 International Journal of Molecular Sciences
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Dissecting the contribution of O-Antigen and proteins to the immunogenicity of Shigella sonnei generalized modules for membrane antigens (GMMA).

2021 Scientific Reports
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Rationalizing the design of a broad coverage Shigella vaccine based on evaluation of immunological cross-reactivity among S. flexneri serotypes.

2021 PLOS Neglected Tropical Diseases
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Generalized Modules for Membrane Antigens as Carrier for Polysaccharides: Impact of Sugar Length, Density, and Attachment Site on the Immune Response Elicited in Animal Models.

2021 Frontiers in Immunology
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Increasing the High Throughput of a Luminescence-Based Serum Bactericidal Assay (L-SBA)

2021
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Antibodies Elicited by the Shigella sonnei GMMA Vaccine in Adults Trigger Complement-Mediated Serum Bactericidal Activity: Results From a Phase 1 Dose Escalation Trial Followed by a Booster Extension.

2021 Frontiers in Immunology
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Impact of O-Acetylation on S. flexneri 1b and 2a O-Antigen Immunogenicity in Mice

2021
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Effect of O-Antigen Chain Length Regulation on the Immunogenicity of Shigella and Salmonella Generalized Modules for Membrane Antigens (GMMA)

2021 International Journal of Molecular Sciences
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