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Guoyan G. Xu

Nankai University

22

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274

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Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease

2017 Molecular Pharmaceutics
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Vzhe-039, a Novel Structurally-Enhanced Allosteric Hemoglobin Effector Inhibits Sickling of SS Erythrocytes In Vitro, and Exhibits Improved Pharmacologic Properties In Vivo

2016 Blood
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Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

2016 Oncotarget
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Exploration on natural product anibamine side chain modification toward development of novel CCR5 antagonists and potential anti-prostate cancer agents.

2015 Bioorganic & Medicinal Chemistry Letters
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Chemokine Receptor CCR5 Antagonist Maraviroc: Medicinal Chemistry and Clinical Applications

2014 Current Topics in Medicinal Chemistry
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Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase.

2013 Biochemistry
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Cyclohexyl ketone inhibitors of Pin1 dock in a trans-diaxial cyclohexane conformation.

2012 PLOS ONE
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A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state.

2011 Biochemistry
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Cycloaddition of nitrile oxides to substituted vinylphosphonates

2003 Heteroatom Chemistry
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Cycloaddition of nitrile oxides to substituted vinylphosphonates

2003 Heteroatom Chemistry
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